Health benefits from HMOs

Inbiose designed and set up a technology platform allowing the cost-competitive production of human milk bioactives also called Human Milk Oligosaccharides (HMO).

We offer innovative ingredients towards infant food formula manufacturers and novel prebiotics and nutrition ingredients focused companies.

What are human milk oligosaccharides?

Along multiple biological activities they have been attributed prebiotic effects, health benefits (inhibition of the adhesion of pathogens on epithelial surface and to interact directly with immune system), and effects on postnatal brain development.

Market potential

  • Infant food formula (milk bioactives).
  • Fortified and functional food/beverages.
  • Health ingredients for human and animal.
  • Over the counter food supplements.

Biofermentation of HMOs

Why Inbiose developed a biofermentation process for HMO?

Human milk oligosaccharides are high added-value complex carbohydrates. Production of HMO by enzymatic engineering and chemical synthesis has been hindered by structure complexity and related costs that render industrial production difficult. The fermentation process Inbiose developed, is cost and time effective allowing an interesting economy of scale with industrial compatible cost and yield for each developed HMO product.

Inbiose can supply purified human milk oligosaccharides: sialylated and fucosylated compounds. Would you like to know us better and partner up with an supplier of standardised human milk oligosaccharides? Please feel free to contact us for any tailored or specific demand fitting your requirements

Scientific and general information

What are Prebiotics?

Non-digestible food ingredients mostly of a carbohydrate base that improve human health by selectively stimulating the growth and/or activity of existing bacteria in the colon.

What are Probiotics?

Live microbial dietary supplements beneficially affect the host animal by improving its intestinal microbial balance. Antibiotics and other related compounds are not included in this definition. In humans, lactobacilli are commonly used as probiotics, either as single species or in mixed culture with other bacteria. Other genera that have been used are bifidobacteria and streptococci.

Interesting literature

Biotechnological production of human milk oligosaccharides. N.S. Han et al. 2012. Biotechnology Advances, 30 1268–1278.

Human Milk Oligosaccharides: Every Baby needs a Sugar Mama. L Bode. 2012. Glycobiology, 22, 1147-1162.

Oligosaccharides from Milk. G Boehm and B Stahl. 2007. Journal of Nutrition, 137, 847S-849S.

Structures and application of oligosaccharides in human milk. A Kobata. 2010. Proceedings of the Japan Academy, 86, 731-749.

Milk intelligence: Mining milk for bioactive substances associated with human health. S Mills et al. 2011. International dairy journal, 21, 377-401.

Companies talk about HMOs

Mead Johnson Nutrition: Prebiotics in Infant Nutrition

Danone nutrition: G Boehm and B Stahl. Oligosaccharides. 2003. In Functional dairy products. p203-243. T Mattila-Sandholm and M Saarela, Editors. Boca Raton: CRC Press.